Breaking news: Oprah sent her first tweet during a taping of her talk show today (April 17).

The audience cheered as Lady O typed “ASHTON IS NEXT” on a laptop this morning and sent the message on the social networking site Twitter.

She was welcomed onto the site with messages from George Stephanopoulos, Ellen DeGeneres, Jimmy Fallon and Shaquille O’Neal.

Later in the show, Oprah added tweets of thanks for the welcome and updates about her dog getting its rabies vaccine.

History in the making.

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